Author: Orlando E

Emergence of Biotechnology Platforms During COVID-19: A Lesson in Modern Biology

http://s.uconn.edu/meseminar10/8/21

Abstract: The COVID-19 pandemic has accelerated the development and manufacturing of vaccines at an unprecedented speed. This has been enabled by the emergence of biotechnology platforms such as mRNA and Viral Vectors. In this seminar, I will outline the engineering aspects of such platforms and the modern biology behind their evolution.

Biographical Sketch: Dr. Vijay Srinivasan is a Senior Advisor in the Engineering Laboratory at the National Institute of Standards and Technology, Gaithersburg, Maryland. He joined NIST in 2009, after 26 years at IBM Research during which he was also an Adjunct Professor at the Columbia University, New York. Dr. Srinivasan has published widely and is a Fellow of ASME and AAAS.

A Methodical Approach to System Architecture

http://s.uconn.edu/meseminar10/1/21

Abstract: The development of aerospace products suffers from chronic cost and schedule overruns and derivative designs, while innovative products are needed on time and on budget.  We’ll examine the primary failure modes of conventional system-architecting practice that have led to these symptoms and how to avoid them.  We’ll consider how to answer the 5 key questions with which product-development teams struggle – how to determine the best performance achievable given a set of technologies, how to find a small diverse set of high-value architectures, how to identify the technology options that are critical for early investment before the final architecture is selected, how to set technology-development targets, and how to know what properties a new technology would need to be worth its development.  People are actually poorly suited to certain architecting tasks; we’ll describe how people’s skills tell us to which architecting tasks they’re really well suited to contribute.  Finally, we’ll describe a methodical approach to system architecture that researchers at Raytheon Technologies Research Center have been developing and successfully applying for product architecting across RTX.

Biographical Sketch: Dr. Zeidner leads the development and application of RTX’s DISCOVER ecosystem of advanced methods and tools for the conceptual design of RTX products, from the component level of product engineering, all the way up to the campaign level of multi-product operations. Dr. Zeidner has 25 years of experience in the development of system architectural-design methods and collaborative processes and tools for engineering innovation and decision-making.  His areas of expertise include design-space exploration, system modeling, risk analysis and software architecture. While at RTX, he has developed the Concept Generation and Selection (CGS) process, which has been successfully applied to over 200 projects across RTX’s business units, enabling large, non-collocated teams to brainstorm productively. He holds 4 patents and has earned fifteen internal RTRC awards for technical achievement. Prior to joining RTRC, Dr. Zeidner taught and conducted research as an Assistant Professor of Manufacturing Engineering at Boston University on the topics of design-to-manufacture and advanced software-development methods.  Dr. Zeidner obtained his PhD in Civil Engineering in 1983 from Princeton University.

Mechanical Safety of Lithium-ion batteries for Electric Vehicle Applications

http://s.uconn.edu/meseminar9/24

Password: 1234

Abstract: Lithium-ion batteries have been used extensively in the past decade in a variety of applications from portable devices to airplanes and electric vehicles. Battery packages used in electric vehicles experience dynamic loadings, shocks, and large deformations during normal operation as well as in a crash scenario. It is of paramount importance to battery manufacturers and the automotive industry to better understand how the cells deform under such loadings and what conditions might damage a cell and lead to failure. This talk will focus on the experimental methods used to characterize material properties of lithium-ion batteries under large mechanical loading. Then deployments of these material models for simulating crash response of batteries will be discussed. The models that will be discussed are capable of predicting the profile of deformation and the onset of short circuit in batteries in the cases of mechanical abusive loads.

Biographical Sketch: Elham Sahraei is an Assistant Professor and Director of Electric Vehicle Safety Lab at Temple University. She was the co-director of the MIT Battery Modeling Consortium, a multi-sponsor industrial program supported by major automotive and battery manufacturers from 2011 till 2019. Her research is focused on computational modeling of lithium-ion batteries for electric vehicles. Dr. Sahraei earned her Ph.D. from the George Washington University in 2011, and completed two years of post-doctoral training at Massachusetts Institute of Technology in 2013, where she became a Research Scientist afterwards. She is currently a principal investigator on safety of lithium-ion batteries under combined mechanical-electrical loading for Office of Naval Research. She has also been an investigator on several Ford-MIT alliance projects, and she is the inventor of “Collision Safety Structure,” a structure for controlled buckling of driver seats that reduces perils of frontal crashes.

Leverage Machine Learning and Simulation for Polymer Screening and Design

http://s.uconn.edu/meseminar9/17/21

Abstract: Developing polymers with desirable properties has historically relied on trial-and-error, which can take long time, and there is no guarantee of success. Machine learning has become an integral part of materials design, and it can potentially impact polymer development in a positive way. However, the lack of open-source data has impeded the development of machine learning-guided polymer development, i.e., polymer informatics. In this talk, I will discuss our effort in generating polymer structures using machine learning models trained on existing polymer database. I will describe the process we used to generate the PI1M database (PI1M refers to 1 million polymers for Polymer Informatics) . I will also talk about the challenges ahead of the continued research in this direction. In addition, I will introduce our work in generating polymer properties using molecular dynamics simulations and discuss the challenges to be addressed. Machine learning models for several polymer properties (e.g., thermal properties, gas separation performance) will be presented. I will also highlight the need of a greater community effort to advance the polymer informatics field.

 

Biographical Sketch: Dr. Tengfei Luo is a Professor in the Department of Aerospace and Mechanical Engineering (AME) with a concurrent appointment in the Department of Chemical and Biomolecular Engineering (CBE) at the University of Notre Dame (UND). Before joining UND, he was a postdoctoral associate at MIT (2009-2011) after obtaining his PhD from Michigan State University (2009). Dr. Luo’s research focuses on exploring the chemistry-conformation-property relationships of polymers using molecular simulations, machine learning and experiments. He is an ASME Fellow (2019), JSPS Invitational Fellow (2019), DuPont Young Professor Awardee (2016), DARPA Young Faculty Awardee (2015), and Air Force Summer Faculty Fellow (2015). 

The role of first principles in problem solving in the “AI” era

http://s.uconn.edu/meseminar9/10/21

Abstract: It is commonly believed that understanding, building, and controlling complex engineering systems require data-driven methods beyond first principles. Often these methods are boasted as “AI”. Yet data-driven methods are known to lack risk certification, i.e., we don’t have principled knowledge about when they will fail or how badly if they do. This challenge has created a recent surge of efforts in “baking” first principles into data-driven methods, leading to new learning theories, algorithms, and applications. In this talk, I will go through three studies across the spectrum where first principles play a significant role in mitigating the risks induced by data-driven models. The first study investigates an optimal solution generator governed by the Karush-Kuhn-Tucker conditions, with applications to accelerating topology optimization. The second discusses the approximation of open-loop solutions to the Hamilton-Jacobi-Isaacs equations for incomplete-information differential games, with applications to safer human-robot interactions. The last investigates certifiable attribution of generative models, with applications to DeepFake regulation.

 

Biographical Sketch: Dr. Yi Ren is an Assistant Professor with the Department of Aerospace and Mechanical Engineering at Arizona State University. He got his BEng in Automotive Engineering from Tsinghua University in 2007 and his PhD in Mechanical Engineering in 2012 from the University of Michigan, Ann Arbor, where he also worked as a Postdoc before moving to ASU in 2015. His research focuses on developing robust machine learning methods for risk-sensitive engineering systems, with applications to structure/materials design and autonomous driving. He has won multiple NSF grants from system engineering, materials science, robotics, and cybersecurity programs, the Amazon Machine Learning Award (2019), and the Best Paper Award at the ASME International Design and Engineering Technical Conferences (2015). He leads the planning of an ASU NSF AI institute for 4D materials design.

UConn ME selected by NASA to Develop Moon to Mars Mission Design Ideas

UCONN has been selected as one of six universities to participate in NASA’s 2022 Moon to Mars eXploration Systems and Habitation (M2M X-Hab) Challenge. NASA’s selection, in partnership with the National Space Grant Foundation, will develop innovative design ideas that will help NASA advance and execute its Moon to Mars exploration objectives. 

This year’s winning M2M X-Hab Challenge teams will design, manufacture, assemble, test, and demonstrate functional prototype subsystems and innovations that enable increased functionality for human space exploration missions.

Profs. Vito Moreno and Jason Lee are leading the charge at UCONN in collaboration with Jorge Paricio Garcia and Ed Weingart, the Co-Directors of the UCONN Krenicki Arts and Engineering Institute, Patrick Kumavor (Biomedical Engineering), and Christopher Sancomb (Art/Industrial Design). The multidisciplinary concepts that they submitted will be developed into proof of concept 1/6-G suited prototypes to be applied in field environments. The first design will use weather balloons and drones and associated control and feedback software with a wearable harness. The weather balloon will offset the analog astronaut’s weight, while the drone and sensors will fine-tune responses to movements, produce a lifting force needed to simulate reduced gravity, and keep the balloon hovering above the astronaut. The second design, using the NASA ARGOS concept as a base, will incorporate a mobile platform that moves with the individual, and a counterweight system to simulate reduced gravity. Both projects will be an important element of the Senior Design projects for the departments of Mechanical Engineering as well as Biomedical Engineering in collaboration with the Industrial Design and Fine Arts programs. A diverse student team will also work with Aquiline Drones (Hartford) and Wallingford K-12 Public School’s Center for Innovation and Design: An Aerospace Experience to Mars.

Prof. Pierce joins the Editorial Board of the ASME Journal of Biomechanical Engineering

Dr. David M. Pierce, Associate Professor of Mechanical Engineering and Biomedical Engineering, has been named Associate Editor of the ASME Journal of Biomechanical Engineering. This archival journal reports research results involving the application of mechanical engineering principles to the improvement of human health. The scope of relevant topics ranges from basic biology to biomedical applications and includes theoretical, computational, experimental, and clinical studies.

The driving interest of his research is to understand and predict the mechanics of soft tissues and engineering materials. His current work employs theoretical, computational, and experimental tools to explore the interplay of form and function in cartilage, specifically the multiscale and multi-phase mechanics and how these evolve in health, damage, and disease. Dr. Pierce is a 2017 NSF CAREER awardee and a United Technologies Corporation Professor in Engineering Innovation in the School of Engineering. He also serves as a Journal Referee for over 50 peer-reviewed, academic journals.

Artificial intelligence for structural materials design and manufacturing

http://s.uconn.edu/meseminar4/23/21

Abstract: After billions of years of evolution, it is no surprise that biological materials are treated as an invaluable source of inspiration in the search for new materials. Additionally, developments in computation spurred the fourth paradigm of materials discovery and design using artificial intelligence. Our research aims to advance design and manufacturing processes to create the next generation of high-performance engineering and biological materials by harnessing techniques integrating artificial intelligence, Multiphysics modeling, and multiscale experimental characterization. This work combines computational methods and algorithms to investigate design principles and mechanisms embedded in materials with superior properties, including bioinspired materials. Additionally, we develop and implement deep learning algorithms to detect and resolve problems in current additive manufacturing technologies, allowing for automated quality assessment and the creation of functional and reliable structural materials. These advances will find applications in robotic devices, energy storage technologies, orthopedic implants, among many others. In the future, this algorithmically driven approach will enable materials-by-design of complex architectures, opening up new avenues of research on advanced materials with specific functions and desired properties.

Biographical Sketch: Grace X. Gu is an Assistant Professor of Mechanical Engineering at the University of California, Berkeley. She received her PhD and MS in Mechanical Engineering from the Massachusetts Institute of Technology and her BS in Mechanical Engineering from the University of Michigan, Ann Arbor. Her current research focuses on creating new materials with superior properties for mechanical, biological, and energy applications using multiphysics modeling, artificial intelligence, and high-throughput computing, as well as developing intelligent additive manufacturing technologies to realize complex material designs previously impossible. Gu is the recipient of several awards, including the 3M Non-Tenured Faculty Award, MIT Technology Review 35 Innovators Under 35, Johnson & Johnson Women in STEM2D Scholars Award, Royal Society of Chemistry Materials Horizons Outstanding Paper Prize, and SME Outstanding Young Manufacturing Engineer Award.

Tianfeng Lu elected as a Combustion Institute (CI) Fellow

We are proud to announce that Mechanical Engineering Professor Tianfeng Lu has been recognized as one of the 2021 Class of Fellows for The Combustion Institute.

Prof. Lu joins a class of 32 accomplished international scholars from industry, academia, and the public sector, and was recognized for “the development of computationally efficient and accurate methods for the systematic, efficient and massive reduction of large reaction mechanisms.”

Dr. Lu received his B.S. and MS degrees in 1994 and 1997 respectively, both in Engineering Mechanics and both from Tsinghua University, followed by his Ph.D. degree in 2004 from Princeton University in Mechanical and Aerospace Engineering. He joined UConn as an Assistant Professor in August 2008 after spending 4 years in research positions at Princeton. His research focuses on computational combustion with special interests in reduced chemical kinetics, stiff chemistry solvers, and computational diagnostics of laminar and turbulent flames.